Port of Spain General Hospital is a public hospital in Port of Spain, Trinidad and Tobago. The main building was once a Colonial hospital that began construction in 1854, using local stone and imported brick facing to provide a Classical style facade. The official opening of the hospital was in 1858. The exterior has been maintained while the interior has been adapted for modern medical practice, mostly in work around 1960 directed by the UK architects Devereux and Davies and including murals by the Trinidadian artist Althea McNish.